Some studies even suggest(11) that temporary supraphysiologic dosing of T3 may help to overcome these hormone imbalances, provided it is used safely and correctly. This guide will teach you everything you need to know about using Armour thyroid ranging from who should use it, how to use it safely, how to use it for weight loss and common pitfalls patients experience. This is sometimes used by the physician as "proof" that Armour thyroid doesn't work. After all - If weight loss were that simple, then Doctors would be prescribing low doses of Armour to every patient! Patients can take advantage of this increased potency and may actually feel much better when switching from other medications to Armour thyroid. T3 can be added to Armour thyroid with the following medications: liothyronine, Cytomel or SR T3. So how does this relate to Armour thyroid? Which means Armour thyroid may more closely approximate what your body produces in a natural and healthy state. Calcium Supplements and Thyroid Absorption: What to Know, Thyroid Supplement Side Effects: What to Expect. As they increase they are supposed to tell your brain to increase metabolism and start burning off that extra fat you just gained. Design and setting: Patients with leptin resistance generally require higher levels of T3 only medications to help reduce the T4 to reverse T3 conversion that occurs with this condition. The portion of T3 thyroid hormone in each "grain" (which is a unit of Armour thyroid dosing) is actually still quite small: Doctors know that T3 it is approximately 3.3 times more effective at dropping the TSH than T4 medication alone (9) (Synthroid and levothyroxine). Are there any downsides to using Armour thyroid? If you decide that Armour thyroid is worth trying, then how do you dose it? For various reasons, physicians may be relying on tests that may not accurately identify the status of thyroid hormone in the body. These special properties may be one of the reasons that patients who switch to Armour thyroid experience significant improvement in their hypothyroid symptoms. Unfortunately, many patients with hypothyroidism also have gastrointestinal issues including low stomach acid (15). Patients in this category include those with higher metabolic demands (those with a higher metabolism), patients who are overweight or who have a higher than average BMI and patients who may be taking medications that block or limit thyroid hormone action. Another strategy that I often recommend is to simply take your thyroid medication at night. The .gov means its official. Outcome measures: You can read more about this idea in detail here. If you have more than that to lose there is a good chance your extra weight is from something else entirely. Reverse T3 Treatment Guide + How to Flush it out of Your Body & Start Feeling Better Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. In addition, these inactive ingredients may alter the breakdown and digestion of which then alters the absorption of thyroid hormone in the body. In some cases, this may be as easy as adding a small dose of T3, in others, it may mean switching to individual T4 and T3 prescriptions. While Armour Thyroid is a great medication (that will probably help reduce your symptoms even if it doesn't help you lose weight) it usually isn't enough for weight loss by itself. Taking thyroid medication on an empty stomach is usually recommended by physicians and pharmacists because this action may help your body increase absorption. Patients who need more T3 usually fall into one or more of the following categories: If you fall into any of the categories above AND you aren't losing weight on Armour thyroid then you may want to consider adjusting the individual dosing of T3 and T4 in your medication. Are you taking Armour Thyroid? Leptin resistance is often accompanied by insulin resistance and thyroid resistance (all three conditions are caused by the same thing). Reasons to use or stick with Levothyroxine/Synthroid: Instead of focusing on which is the "best" thyroid medication it's more helpful to determine (through testing and symptom management) which is the best thyroid medication for YOUR body. So your total dose stays the same but you are "splitting" that dose throughout the day. Clin Case Rep. 2022 Apr 12;10(4):e05651. Armour thyroid is ranked among a class of thyroid medications known as Natural Desiccated thyroid medications. I am a former Doctor of Osteopathic Medicine (no longer practicing) that now focuses on producing the information you see here while also formulating some of the best supplements on the market (in my HUMBLE opinion) :). While Armour does contain some T3 it is possible that your body may actually need more. Restart Medical LLC. Each grain gives you 38mcg of T4 and 9mcg of T3. Patients who still have a thyroid gland that functions may be able to produce T1 and T2 in sufficient amounts to not notice a difference, but either way it's worth discussing. Chaker L, Razvi S, Bensenor IM, Azizi F, Pearce EN, Peeters RP. Clipboard, Search History, and several other advanced features are temporarily unavailable. Reverse T3 = INACTIVE thyroid metabolite that competes with T3 for cellular binding. In this system, your body takes the inactive thyroid hormone T4 and it can activate it by turning it into T3. Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. Need more help? Since this testing is not mainstream (yet!) It can also "inactive" it if it doesn't need any extra thyroid hormone by turning it into reverse T3. #2. Armour thyroid is special when compared to levothyroxine because it contains at least two types of thyroid hormone: T4 and T3. While none of these are hard and fast rules they can help you get started. Beyond Armour thyroid, there are other types of natural desiccated thyroid such as Nature-throid and WP Thyroid. 2021 Oct 21;106(11):e4400-e4413. This is ok for some patients but doesn't allow for altering individual dosing of the T4 and T3 if necessary. That is the question that many patients have and one of the main reasons they want to at least give Armour thyroid a try. This leads to a situation where you will have the symptoms of hypothyroidism but your lab tests may be "normal". So if you are taking 2 grains total each day you might consider taking 1 grain in the morning and then another in the afternoon. In my experience, (and if used safely) lowering T4 dosing and increasing T3 dosing provides improved weight loss and improved lipid metabolism in a subset of patients. But emerging research(6) is showing that these compounds are still important nonetheless, even if we don't completely understand what they do or how they work. Biochemical and neurocognitive tests at baseline and at the end of each treatment period were evaluated. Activation or conversion are both words for the same process: The turning of inactive T4 into active T3. Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC. Accessibility Welcome to my website! So suggesting that 1 grain of T4 (which equals about 65mcg) is a substitute for 100mcg of T4 is not necessarily a fair assumption. Thyroid. This sort of reaction tends to be rare, provided you slowly increase your dose over time and monitor your serum thyroid levels as you go. If you use the calculation above then 2 grains is equal to 120mg of Armour thyroid or 130mcg of T4 equivalents (if you convert the 18mcg of T3 into T4). Not all forms of Natural Desiccated thyroid are created equal. Why Levothyroxine Causes Weight Gain and How to Prevent it, Reverse T3 Treatment Guide + How to Flush it out of Your Body & Start Feeling Better, The Complete Guide to using Nature-Throid for Thyroid Patients, What Your Low TSH Means With Thyroid Medication & Without. then you should have your blood work retested and evaluated. If this happens to you don't let it scare you from using the medication further! This content is strictly the opinion of Dr. Westin Childs and is for educational and information purposes only. New research has shown(7) that there are some existing genes known as SNP's that may alter the efficiency of this conversion process. Again it's not the difference in the concentration of thyroid hormone in each individual medication but most likely a reflection of digestion and absorption. It's important to remember that Armour thyroid comes from an animal and animal tissue is considered "foreign" to your body. It would be silly of us to assume that simply because we don't know what they do or how they work that they are unimportant, but that is kind of the mentality that we have when it comes to the human body. JAMA. Case Rep Endocrinol. Maca and Your Thyroid: Harmful or Helpful? Because the conventional treatment for patients with hypothyroidism is to supplement with only the inactive thyroid hormone T4. We conducted a randomized, double-blind, crossover study at a tertiary care center. I know it sounds weird but it works incredibly well for several reasons: When your thyroid is functioning at 100% it naturally produces 2 thyroid hormones each and every day. Check out my free thyroid downloads and resources. But remember that each grain of Armour thyroid only has 38mcg of T4 and 9 mcg of T3. Leptin levels can be tested easily in the serum and fasting leptin levels higher than 10-12 indicate the presence of leptin resistance. These other thyroid hormones, known as T1 and T2, also exist in your body but they don't get much credit because they are considered to be "less biologically active" than T4 and T3. This means that some of you out there are just not very good at converting T4 into T3(8) while some of you out there are incredible at doing it. official website and that any information you provide is encrypted DTE therapy may be relevant for some hypothyroid patients. This approach will help you achieve long lasting results and help improve your symptoms more than any other. HHS Vulnerability Disclosure, Help Because high levels of reverse T3 can be caused by different factors, the best way to treat it is to identify the cause and focus on that issue. Ahmed ZS, Sherin RPV, Fonseca TL, Hoang TD, Shakir MKM. Let's recap this information because it can be confusing: The healthy thyroid gland naturally produces about 80% T4 thyroid hormone and about 20% T3 thyroid hormone(4) each and every day. Another reason that physicians may not be adequately dosing certain patients is that they are unfamiliar with dosing thyroid medications that contain T3. New Study Explained. One of the biggest (and perhaps more important) question that most patients have when considering Armour thyroid is this: Will Armour Thyroid actually help me lose weight? In physiology, we give all of the credit to T3 because it is the most biological thyroid compound floating around in your blood. Patients lost 3 lb on DTE treatment (172.9 36.4 lb vs 175.7 37.7 lb, P < .001). Thyroid dosing is highly individualized and depends on factors such as your current metabolic rate, your sensitivity to T3 and your peripheral thyroid conversion status. The "slow release" comes from the fact that it is harder to digest and absorb in the body, but this also reduces the overall amount of hormone available in each dosage. Your body lives in harmony and functions optimally when it can create the amount of T4 and T3 that it needs on a daily basis. Meaning the amount of T3 in each grain of Armour is always the same (this is a good thing from a pharmaceutical and consistency standpoint, but may be a problem due to the inability to titrate individual T3 and T4 doses). This process is controlled by various factors including your genetics so it may come as no surprise that some people are "better" at converting thyroid hormone than others. As a general rule of thumb (though not always accurate) certain patients tend to need higher doses of thyroid hormone. Two things should pop out to you after reading that list: 1) Thyroid medications containing T4 may contribute to elevated reverse T3 levels. .wp-show-posts-columns#wpsp-90491 {margin-left: -2em; }.wp-show-posts-columns#wpsp-90491 .wp-show-posts-inner {margin: 0 0 2em 2em; } If you aren't familiar with Reverse T3 please read this article. It turns out that many conditions may be sabotaging your thyroid conversion and the presence of these conditions may be causing your body to turn T4 into reverse T3. This is also confirmed with studies(12) which have shown that transition from T4 to T3 dosing (based off of pituitary and TSH testing) improves all of these markers. 2022 Dr. Westin Childs | Thyroid & Health Supplements That Work Built withGeneratePress and powered by Kinsta. 2004 Jun;60(6):750-7. doi: 10.1111/j.1365-2265.2004.02050.x. Take away from supplements that contain Calcium and Iron but pretty much avoid all supplements if possible. I wouldn't jump to that conclusion right away, but there are certainly some reasons that you should consider using Armour thyroid. As you probably know hypothyroidism is a condition in the body which results in a decreased production or utilization of thyroid hormone in the body. Using the table below you can see that the NDT form of thyroid hormone with the least amount of ingredients is WP thyroid - though this doesn't necessarily mean that it is the "best". I've even had patients who report that when they switch to Armour thyroid their TSH increases and the physician then states that Armour thyroid is unreliable. Bookshelf These hormones (along with probably other enzymes and hormone precursors) are present in the thyroid gland of animals and therefore make it into the pharmaceutical medication as it is prepared. Another strategy worth considering is to split your dose throughout the day. It's also important to note that many providers aren't as comfortable dosing Armour Thyroid as they are levothyroxine and so they will intentionally under dose patients because they are concerned about side effects. Armour thyroid is unique among thyroid medications in that it contains both the active AND inactive thyroid hormones (1). If you transitioned from Levothyroxine (T4 only medication) then you should know how to properly convert your medication. If you fall into this category then you need to make sure that you are "converting" your dose correctly as we outlined at the beginning of this post. Levothyroxine Dosage Guide: Are you on the Right Dose? This means that you can never use a "dosing calculator" to simply determine what your dose should be, instead you may need to use a combination of trial and error along with frequent laboratory testing. You can think about methylcellulose as a glue which holds on tight to the thyroid hormone component of the medication and in order for your body to absorb (and properly utilize) your intestinal tract must separate the methylcellulose from the active thyroid hormone. and transmitted securely. But did you know that there are other thyroid hormones? Results: Add Back Therapy for Graves & Hyperthyroidism: When to use Levothyroxine, Does Levothyroxine Cause Cancer? Physicians, such as endocrinologists, give patients T4 only thyroid medications because they assume that each patient(2) will be able to perfectly convert the inactive thyroid hormone T4 into the active thyroid hormone T3. What Your Low TSH Means With Thyroid Medication & Without PMC The presence of leptin resistance creates hormonal havoc which results in weight loss resistance despite changes to your diet and to the amount that you exercise. I've discussed the thyroid hormone obesity myth in detail and you can read more about this unique approach to weight loss in thyroid patients here. These medications are created by desiccating (or crushing) up the thyroid glands of certain animals - in this case, pigs. doi: 10.1210/clinem/dgab478. Objective: All rights reserved. Primary hypothyroidism and quality of life. Patients with leptin resistance generally require aggressive treatment to reverse leptin levels to help with weight loss. Does Cytomel Help with Weight Loss? Want to know why I'm so passionate about these topics? If you experience any of these symptoms you should seek help with your physician immediately. Armour Thyroid vs Levothyroxine & Synthroid. A more accurate conversion process may look something like this: A couple of important points when considering this information: If you are transitioning from a T4 only medication do NOT start yourself off at the maximum dose of Armour. Along this same vein, it's also possible that your dose of T4 may be either too high or too low relative to your dose of T3. In reality, it may be more accurate that the patient was underdosed which resulted in a hypothyroid state and a subsequent increase in the TSH. And it is these inactive ingredients that may cause certain people to respond well (or not) to these medications due to how they react to these inactive ingredients. If you have high levels of insulin - your focus should be on reversing this condition. If you have questions regarding your health you should seek qualified information from a medical professional or your doctor. To play it safe I generally recommend that you wait 4 hours after taking any supplement before you also take your thyroid medication. Thyroid hormone can bind to certain substances which may reduce the dose of thyroid medication that is delivered to your body. Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. Check out my own personal health story. I'm Westin Childs D.O. These symptoms tend to be unique in the sense that they are NOT caused by the active thyroid hormone but instead caused by the other "stuff" that the medication is formulated with. As a result patients with a "sluggish" thyroid often experience symptoms such as weight gain, fatigue, cold extremities, constipation and so on. If your T4 containing medication is too high you may need to decrease your T4 dose and/or increase your T3 dose. P.S. Federal government websites often end in .gov or .mil. The real question is what do you do about it? As fat cells grow, leptin levels increase. I love to write and share what I've learned over the years. This may result in decreased absorption of thyroid hormone or cause a "delayed" release of the medication into the blood stream. Armour Thyroid is a great medication and it CAN help you lose weight but it is not a magic weight loss pill. The Complete Guide to using Nature-Throid for Thyroid Patients 2022 Apr;18(4):230-242. doi: 10.1038/s41574-021-00625-8. The site is secure. 2011 Nov;96(11):3466-74. doi: 10.1210/jc.2011-1329. may require more T3 relative to T4. I go to great lengths to help my users better understand their health; however, the content you see here is not a substitute for medical advice. DTE therapy did not result in a significant improvement in quality of life; however, DTE caused modest weight loss and nearly half (48.6%) of the study patients expressed preference for DTE over L-T. sharing sensitive information, make sure youre on a federal I made this point #1 because I think it is probably the most important feature which separates Armour from levothyroxine but it certainly isn't the only one: I've found that these 10 foods cause the most problems for thyroid patients. These patients also often experience a worsening in hypothyroid symptoms such as an acute increase in fatigue an increase in weight gain, etc. Leptin is a hormone that is pumped out by your fat cells (yes they pump out hormones!). Levothyroxine, on the other hand, only contains T4. There were no differences in symptoms and neurocognitive measurements between the 2 therapies. It may be no wonder why some patients who "transition" to Armour thyroid often feel symptomatically worse during the transition. I mentioned previously that Armour thyroid is more "potent" and more "active" than T4 medications such as Levothyroxine and Synthroid and part of this is because it contains the active T3 hormone but another important part is that it doesn't require as much activation. This resource is dedicated to helping people with thyroid problems, hormone imbalances, and weight loss problems get the help that they need. How do you know if you are someone who needs more T3? These conditions are characterized by physiologic changes in which the patient may require higher doses of T3 to saturate cellular receptors and allow thyroid hormone to get into the cells. Armour thyroid can be dosed in milligrams or in grains and it's important to understand the difference. These extra hormones may not be of benefit to each and every person but it is certainly possible that patients who don't have a functioning thyroid (such as those who have had it surgically removed) may benefit from the extra T1 and T2 that comes in this medication. This change is not necessarily indicative of the failure of Armour thyroid but more a failure with the conversion and dosing process. Celi FS, Zemskova M, Linderman JD, Smith S, Drinkard B, Sachdev V, Skarulis MC, Kozlosky M, Csako G, Costello R, Pucino F. J Clin Endocrinol Metab. I don't practice medicine anymore and instead specialize in helping people like YOU who have thyroid problems, hormone imbalances, and weight loss resistance. Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society. Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy. Many physicians will tend to underdose you on the transition because they aren't familiar with using medications that contain T3. It's important to note that leptin resistance is generally a late finding and usually indicates that heavy metabolic damage has already occurred. Hey There! Unable to load your collection due to an error, Unable to load your delegates due to an error. This includes inactive ingredients such as methylcellulose and dextrose (and many others). Instead, start off on a lower dose and titrate up SLOWLY every 10-14 days. Unfortunately, some people may require higher amounts of T3 due to reasons suchtissue level hypothyroidism,euthyroid sick syndrome/low T3 syndrome,(10) or peripheral thyroid conversion disorders. So let's talk about the 5 main reasons that patients who make the switch to Armour Thyroid don't lose weight and what you can do to FINALLY lose those extra pounds: One of the biggest issues is that many patients may be undertreated or underdosed. ), (Please don't stop taking these medications if you are on them, but consider discussing options with your Doctor), 1 grain = 60mg = 38mcg of T4 and 9 mcg of T3. From conditions like SIBO, Hashimoto's, Food allergies, nutrient deficiencies, medications, etc. Bethesda, MD 20894, Web Policies Learn which foods you should absolutely be avoiding if you have thyroid disease of any type. I've outlined how to treat leptin resistance in this article. Careers. While it's true 1 grain of Armour thyroid contains the same amount of active thyroid hormone (T3 and T4) as a grain of WP thyroid or Naturethroid - these medications differ in the inactive ingredients that they contain. Patients: Even if you assume that T3 is 3x more potent (which isn't the best indicator of biological activity in the body) then you still come up short with this conversion - let's break down the math: 9 mcg of T3 x 3 = 27 mcg of T4 "equivalents" in each grain of Armour thyroid, 38mcg + 27mcg = 65 mcg of T4 "equivalents" in each grain of Armour thyroid total. These changes in inactive ingredients help to explain why some patients react poorly to Armour thyroid with symptoms like headaches, worsening fatigue or rashes - only to find that these symptoms completely resolve upon switching to naturethroid. This means that when transitioning from T4 only medication to Armour thyroid many patients are usually under treated, especially if physicians rely solely on the TSH as an indicator of thyroid status in the body. 2003 Dec 10;290(22):2952-8. doi: 10.1001/jama.290.22.2952. If you've been experiencing any of these symptoms then you should have your blood work retested and evaluated. Dosing Armour thyroid is not much different than using traditional or conventional thyroid medications such as levothyroxine or Synthroid. Reasons to try or consider using Armour thyroid: This is not a complete list but instead focuses on our current understanding of thyroid physiology, genetics, and thyroid conversion and attempts to come up with logical reasons why some patients might feel better on Armour thyroid compared to other medications. If you are naive to thyroid medication (meaning that you have never tried thyroid medication before) then starting off at 15-30mg and titrating slowly up every few weeks may also be appropriate. Please enable it to take advantage of the complete set of features! Nat Rev Dis Primers. Download more free resources on this page. Other factors such as your sex hormone binding globulin may be a better indicator of tissue levels of thyroid hormone. government site. Taking your medication at night offers several advantages: First is that you don't have to worry about taking it on an empty stomach because most people generally don't eat right before bed. Because T4 has the option to turn into T3 or Reverse T3 we need to concern ourselves with what causes the body to preferentially create more reverse T3. Planck T, Lantz M, Perros P, Papini E, Attanasio R, Nagy EV, Hegeds L. Front Endocrinol (Lausanne). When you have leptin resistance (13) the exact opposite happens: your body thinks you're starving so it decreases metabolism and increases appetite (even though you have plenty of fat). Epub 2018 Apr 5. And these patients may simply do better on traditional T4 medications. At the end of the study, 34 patients (48.6%) preferred DTE, 13 (18.6%) preferred L-T, and 23 (32.9%) had no preference. It should be stated that Armour thyroid is not a perfect thyroid medication nor will it necessarily work for every person. Conclusion: eCollection 2021. I also happen to formulate the best supplements on the market (well, at least in my opinion!) And second is that taking your thyroid hormone in the evening may actually improve absorption because the GI tract tends to be slower in the evening (16). If a patient is hypothyroid, meaning their thyroid gland is not producing enough thyroid hormone naturally, then they must undergo thyroid hormone replacement therapy. It should come as no surprise then to hear that you don't want high levels of Reverse T3 because it competes for binding with T3 which creates tissue level hypothyroidism or thyroid resistance. If you are taking 1 grain of Armour thyroid but you take it with a meal, it's possible you may only be absorbing 70% of that 1 grain. If you are transitioning from an existing T4 medication then starting your dose off at about 25% of the maximum and then increasing slowly every few weeks is a safe and effective method.